The short answer is no. I listen to podcasts every day on my 50 mile round-trip commute and I listen to a few, but if someone said I could only pick one, it would definitely be this one (although I would quickly exhaust his entire series, so maybe I'd pick his equally awesome Ask Pat since it's 5 days a week).
At any rate, Pat breaks it down, he inspires, he picks great guests, and he varies the topics a lot, but if you have any hope of starting, honing or taking your online business to the next level, his podcast is a must-listen!
Thanks Pat!