People think they know John C. Reilly. There's something about his performances that seem so familiar, even though he doesn't like to reveal much about himself personally. Marc tries to pull the curtain back a bit, talking wi...
Deon Cole didn't think he would become a comedian when he was growing up on the South Side of Chicago. But now with a new comedy special, acting roles on two hit TV shows and continued success on Conan, Deon tells Marc how it...
Neil Young. There's not a lot you need to say in introducing a legendary musician with three dozen studio albums spanning five decades. Neil joins Marc in the garage to talk about his music, his family, his friends, his guita...
Chelsea Handler is embarking on a brave new world with a weekly talk show on Netflix. But Marc wants to find out if this Chelsea is really any different than the last Chelsea. Awkwardness ensues. Plus, Jen Kirkman stops by to...
Louie Anderson's standup career is unquestionably legendary. But his astounding performance as Christine Baskets has put Louie in an entirely new dimension. Marc and Louie go through it all, from the Midwestern upbringing in ...
Cartoonist and writer Daniel Clowes brings the world of underground comics into Marc's garage. They talk about the great comic artists who paved the way, the difficulty in translating some graphic novels to film, and the simi...
George C. Wolfe is a giant of American theater - directing, producing, and writing some of the most important works of the last 25 years. Fresh of seeing George's latest musical, Shuffle Along, Marc finds out what George wan...
Comedian Joe Wong grew up in China. Then he came to America and learned how to be a standup comic. Now he's back in China, helping to shape the Chinese comedy scene, and starring in his own TV show. Joe talks with Marc about ...
Comedian Chris Gethard and Marc bond over their New Jersey upbringings, but Chris has Marc beat when it comes to unbelievable stories from growing up in the Garden State. They also talk about Viagra, public access TV, and das...
Playwright Stephen Karam received his first Tony nomination about an hour before sitting down with Marc to talk about his experiences in the New York theater community, the way he writes himself into all of his characters, an...
Marc welcomes singer-songwriter Joanna Newsom to the garage, sadly without her harp, although it probably wouldn't fit. Joanna tells Marc how her musical style evolved from composing pieces influenced by American classical mu...
Terry Reid is one of the most talented singers and rock musicians who never had a massive break, but he doesn't seem to sweat it. Terry tells Marc great stories from throughout his expansive career in the music business, and ...
Natasha Leggero is ready to embark on a standup tour with her husband just in time for the premiere of her TV show's second season. Things may be going well now but, as Natasha tells Marc, it wasn't always like that. In fact,...
Sturgill Simpson has all the makings of a classic country star, complete with an upbringing in coal country, a job on the railroad, and the stamp of approval by country music legends. But as Sturgill tells Marc, he's not inte...
Clark Gregg is well known in the Marvel Universe as Agent Coulson from The Avengers and Agents of S.H.I.E.L.D. But as Marc finds out, Clark long ago established himself as a serious actor with The Atlantic Theater Company und...
Ali Wong wants you to know what "leaning in" is like for a working stand-up comic who also happens to be a new mother. Marc talks with Ali about her new life as a mom and her continuing life as a road comic who is bucking con...
Garry Marshall went from writing jokes for comedians in a deli to creating culture-changing television shows and directing blockbuster movies. Garry takes Marc through his entire show business career, from The Tonight Show to...
Rob Reiner has been around show business his entire life, which might explain why he's excelled in so many different areas. Rob shares stories with Marc about Groucho Marx, the Smothers Brothers, All in the Family, Albert Bro...
Steve-O probably could have died several times while making Jackass. But that's nothing compared to the amount of life-threatening danger he faced in real life. Now sober and full of clarity, Steve-O tells Marc talk about his...
It's a two-part 700th Episode extravaganza. First, Marc and Julia Louis-Dreyfus talk Seinfeld, SNL, Second City, Larry David, Woody Allen, Veep, being a mom, and getting older. Then for Part 2, Marc's friend Louis CK stops by...
It's a two-part 700th Episode extravaganza. First, Marc and Julia Louis-Dreyfus talk Seinfeld, SNL, Second City, Larry David, Woody Allen, Veep, being a mom, and getting older. Then for Part 2, Marc's friend Louis CK stops by...
Susan Sarandon achieved tremendous success as an actor, but one career accomplishment remains elusive. She tells Marc about this major goal and why she is willing to split it with Bruce Springsteen. They also talk about her i...
David Simon is the creator of arguably the greatest television show in history. He cemented his reputation as a hard-nosed, truth-seeking journalist. But when David walks into the garage, he's a lot like Marc: A guitar-loving...
Comedian Nikki Glaser and Marc share a bond that might be deeper than love: They share an eating disorder. Nikki and Marc talk about how they've both struggled, where they've found support, and what they needed to fix elsewhe...